Source:  Games    Tag:  adenovirus hexon


Energies, Vol. 5, Pages 1613-1647: Achieving a Green Solution: Limitations and Focus Points for Sustainable Algal Fuels

Posted: 21 May 2012 12:00 AM PDT

Research investigating the potential of producing biofuels from algae has been enjoying a recent revival due to heightened oil prices, uncertain fossil fuel sources and legislative targets aimed at reducing our contribution to climate change. If the concept is to become a reality however, many obstacles need to be overcome. Recent studies have suggested that open ponds provide the most sustainable means of cultivation infrastructure due to their low energy inputs compared to more energy intensive photobioreactors. Most studies have focused on strains of algae which are capable of yielding high oil concentrations combined with high productivity. Yet it is very difficult to cultivate such strains in open ponds as a result of microbial competition and limited radiation-use efficiency. To improve viability, the use of wastewater has been considered by many researchers as a potential source of nutrients with the added benefit of tertiary water treatment however productivity rates are affected and optimal conditions can be difficult to maintain year round. This paper investigates the process streams which are likely to provide the most viable methods of energy recovery from cultivating and processing algal biomass. The key findings are the importance of a flexible approach which depends upon location of the cultivation ponds and the industry targeted. Additionally this study recommends moving towards technologies producing higher energy recoveries such as pyrolysis or anaerobic digestion as opposed to other studies which focused upon biodiesel production.

Energies, Vol. 5, Pages 1593-1612: A Power Smoothing Control Strategy and Optimized Allocation of Battery Capacity Based on Hybrid Storage Energy Technology

Posted: 21 May 2012 12:00 AM PDT

Wind power parallel operation is an effective way to realize the large scale use of wind power, but the fluctuations of power output from wind power units may have great influence on power quality, hence a new method of power smoothing and capacity optimized allocation based on hybrid energy storage technology is proposed in terms of the uncontrollable and unexpected characteristics of wind speed in wind farms. First, power smoothing based on a traditional Inertial Filter is introduced and the relationship between the time constant, its smoothing effect and capacity allocation are analyzed and combined with Proportional Integral Differential (PID) control to realize power smoothing control of wind power. Then wavelet theory is adopted to realize a multi-layer decomposition of power output in some wind farms, a power smoothing model based on hybrid energy storage technology is constructed combining the characteristics of the Super Capacitor (SC) and Battery Energy Storage System (BESS) technologies. The hybrid energy storage system is available for power fluctuations with high frequency-low energy and low frequency-high energy to achieve good smoothing effects compared with a single energy storage system. The power fluctuations filtered by the Wavelet Transform is regarded as the target value of BESS, the charging and discharging control for battery is completed quickly by Model Algorithm Control (MAC). Because of the influence of the inertia and the response speed of the battery, its actual output is not completely equal to the target value which mainly reflects in high-frequency part, the difference part uses SC to compensate and makes the output of battery and SC closer to the target value on the whole. Compared with the traditional Inertial Filter and PID control method, the validity of the model was verified by simulation results. Finally under the premise of power grid standards, the corresponding capacity design had been given to reduce the size of the energy storage devices as far as possible, which has a certain practical engineering value.

Marine Drugs, Vol. 10, Pages 1092-1102: Structure Elucidation and Anticancer Activity of 7-Oxostaurosporine Derivatives from the Brazilian Endemic Tunicate Eudistoma vannamei

Posted: 21 May 2012 12:00 AM PDT

The present study reports the identification of two new staurosporine derivatives, 2-hydroxy-7-oxostaurosporine (1) and 3-hydroxy-7-oxostaurosporine (2), obtained from mid-polar fractions of an aqueous methanol extract of the tunicate Eudistoma vannamei, endemic to the northeast coast of Brazil. The mixture of 1 and 2 displayed IC50 values in the nM range and was up to 14 times more cytotoxic than staurosporine across a panel of tumor cell lines, as evaluated using the MTT assay.

Viruses, Vol. 4, Pages 847-877: Latest Insights on Adenovirus Structure and Assembly

Posted: 21 May 2012 12:00 AM PDT

Adenovirus (AdV) capsid organization is considerably complex, not only because of its large size (~950 Å) and triangulation number (pseudo T = 25), but also because it contains four types of minor proteins in specialized locations modulating the quasi-equivalent icosahedral interactions. Up until 2009, only its major components (hexon, penton, and fiber) had separately been described in atomic detail. Their relationships within the virion, and the location of minor coat proteins, were inferred from combining the known crystal structures with increasingly more detailed cryo-electron microscopy (cryoEM) maps. There was no structural information on assembly intermediates. Later on that year, two reports described the structural differences between the mature and immature adenoviral particle, starting to shed light on the different stages of viral assembly, and giving further insights into the roles of core and minor coat proteins during morphogenesis [1,2]. Finally, in 2010, two papers describing the atomic resolution structure of the complete virion appeared [3,4]. These reports represent a veritable tour de force for two structural biology techniques: X-ray crystallography and cryoEM, as this is the largest macromolecular complex solved at high resolution by either of them. In particular, the cryoEM analysis provided an unprecedented clear picture of the complex protein networks shaping the icosahedral shell. Here I review these latest developments in the field of AdV structural studies.

Molecules, Vol. 17, Pages 6114-6125: Preussianone, a New Flavanone-Chromone Biflavonoid from Garcinia preussii Engl.

Posted: 21 May 2012 12:00 AM PDT

A new flavanone-chromone biflavonoid, preussianone (1), has been isolated from the leaves of Garcinia preussii, along with four known biflavonoids. The absolute stereostructures were elucidated by chemical, spectroscopic, and chiroptical methods. The biological properties of the new biflavonoid against several bacterial strains were evaluated.

Molecules, Vol. 17, Pages 6100-6113: Synthesis and Evaluation of New β-Carboline-3-(4-benzylidene)-4H-oxazol-5-one Derivatives as Antitumor Agents

Posted: 21 May 2012 12:00 AM PDT

In the present work, we report the synthesis and in vitro anticancer and antimicrobial activity evaluation of a new series of 1-substituted-β-carboline derivatives bearing a 4-benzylidene-4H-oxazol-5-one unity at C-3. The compound 2-[1-(4-methoxyphenyl)-9H-β-carbolin-3-yl]-4-(benzylidene)-4H-oxazol-5-one (11) was the most active derivative, exhibiting a potent cytotoxic activity against glioma (U251), prostate (PC-3) and ovarian (OVCAR-03) cancer cell lines with IC50 values of 0.48, 1.50 and 1.07 µM, respectively. An in silico study of the ADME properties of the novel synthesized β-carboline derivatives was also performed.

Tekken Tag Tournament 2 - DLC Characters Video

Posted: 21 May 2012 12:01 AM PDT

This gameplay video for Tekken Tag Tournament 2 features the first four characters featured in the DLC pack: Michelle, Angel, Ancient Ogre, and Kunimitsu.


Read and Post Comments | Get the full article at GameSpot

" Tekken Tag Tournament 2 - DLC Characters Video" was posted by MikeTao on Mon, 21 May 2012 00:01:00 -0700

Scrutiny 1.6.2 - Validate HTML, generate XML sitemaps and more.. (Shareware)

Posted: 21 May 2012 02:06 AM PDT

Scrutiny uses Integrity's tried and tested engine to crawl a site and report broken links. But it does so much more for the webmaster, such as generating an XML sitemap, html validation and essential SEO checks on page title, meta keywords, meta description and headings.

Version 1.6.2:
  • Traps and highlights a certain kind of recursion.
  • A fix and improvements re secure (https:) links. The problem could cause hanging or crashes in certain circumstances.
  • Fixes problem with thread counting which was preventing it working to its full potential
  • Fixes a memory leak so can handle larger sites than previous versions.

  • Mac OS X 10.4.11 or later.

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Integrity 3.8.4 - Scan your website for broken links.. (Free)

Posted: 21 May 2012 02:11 AM PDT

Integrity is an app for webmasters that checks the links and images on your site. Feed Integrity your homepage URL and it will follow internal links to find all of your pages, checking each link and reporting the server response code for each. Information can be exported in a number of formats including an XML sitemap suitable for submission to Google via webmaster tools. On features - I intend Integrity to remain free and to remain a website link checker, no more no less. Note that Scrutiny provides more advanced features such as the ability to crawl pages requiring authentication and webmaster features which go beyond link checking.

Version 3.8.4:
  • Fixes problem of xml sitemap not reading user's setting for update frequency.
  • Fixes a bug which could cause hanging or crashes in certain circumstances.
  • Fixes problem with the threads setting which was preventing it working to its full potential.

  • Mac OS X 10.4.11 or later

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Gallery Grabber QED 1.3.1 - Download graphics from web picture galleries.. (Shareware)

Posted: 21 May 2012 02:29 AM PDT

Gallery Grabber QED is a tool for downloading graphic files from a web-based picture galleries to your hard-drive.

Gallery Grabber can automatically determine the type of web gallery that has been dropped, extracting only the gallery images themselves - leaving banners, thumbnails and page design behind.

When more control is needed; Gallery Grabber's automatic behaviour can be overridden, forcing a gallery to be downloaded using a specific method:

  • Gallery Page - a single Webpage with large gallery images embedded within the page
  • Thumbnail Picture Gallery - a single Webpage with small to medium thumbnail images which lead to larger gallery images
  • Thumbnail Page Gallery - a Webpage with small to medium thumbnail images which lead to other Webpages with embedded gallery images

Version 1.3.1:


  • A fix for certain problem URLs now allows galleries to be downloaded from more websites
  • Now uses media types rather than file extensions to detect images, this also allows galleries to be downloaded from more websites
  • Improvements to the Link Editor window

  • Mac OS X 10.5 or later

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Norton AntiVirus Definitions 05/18/2012 - Virus definitions for Symantec/Norton AntiVirus.. (Updater)

Posted: 21 May 2012 02:01 AM PDT

Norton AntiVirus Definitions are the latest anti-virus detection files. The installer will automatically update Norton AntiVirus virus definitions and engine files to detect and repair the most recently discovered Macintosh viruses. This file is a self-extracting archive which contains the Norton AntiVirus Virus Definitions Installer. Once downloaded and expanded on your hard drive, simply double-click on the Installer and the appropriate files will be installed on your computer.

Version 05/18/2012:
  • Includes the latest virus definitions

  • Mac OS X 10.4 or later
  • Norton AntiVirus 11.x, or Norton AntiVirus 10.2

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Molecules, Vol. 17, Pages 6083-6099: Synthesis and Bioactivity of Secondary Metabolites from Marine Sponges Containing Dibrominated Indolic Systems

Posted: 21 May 2012 12:00 AM PDT

Marine sponges. (e.g., Hyrtios sp., Dragmacidin sp., Aglophenia pleuma, Aplidium cyaneum, Aplidium meridianum.) produce bioactive secondary metabolites involved in their defence mechanisms. Recently it was demonstrated that several of those compounds show a large variety of biological activities against different human diseases with possible applications in medicinal chemistry and in pharmaceutical fields, especially related to the new drug development process. Researchers have focused their attention principally on secondary metabolites with anti-cancer and cytotoxic activities. A common target for these molecules is the cytoskeleton, which has a central role in cellular proliferation, motility, and profusion involved in the metastatic process associate with tumors. In particular, many substances containing brominated indolic rings such as 5,6-dibromotryptamine, 5,6-dibromo-N-methyltryptamine, 5,6-dibromo-N-methyltryptophan (dibromoabrine), 5,6-dibromo-N,N-dimethyltryptamine and 5,6-dibromo-L-hypaphorine isolated from different marine sources, have shown anti-cancer activity, as well as antibiotic and anti-inflammatory properties. Considering the structural correlation between endogenous monoamine serotonin with marine indolic alkaloids 5,6-dibromoabrine and 5,6-dibromotryptamine, a potential use of some dibrominated indolic metabolites in the treatment of depression-related pathologies has also been hypothesized. Due to the potential applications in the treatment of various diseases and the increasing demand of these compounds for biological assays and the difficult of their isolation from marine sources, we report in this review a series of recent syntheses of marine dibrominated indole-containing products.

Molecules, Vol. 17, Pages 6071-6082: Antioxidant, Antimicrobial and Tyrosinase Inhibitory Activities of Xanthones Isolated from Artocarpus obtusus F.M. Jarrett

Posted: 21 May 2012 12:00 AM PDT

One of the most promising plants in biological screening test results of thirteen Artocarpus species was Artocarpus obtusus FM Jarrett and detailed phytochemical investigation of powdered dried bark of the plant has led to the isolation and identification of three xanthones; pyranocycloartobiloxanthone A (1), dihydroartoindonesianin C (2) and pyranocycloartobiloxanthone B (3). These compounds were screened for antioxidant, antimicrobial and tyrosinase inhibitory activities. Pyranocycloartobiloxanthone A (1) exhibited a strong free radical scavenger towards DPPH free radicals with IC50 value of 2 µg/mL with prominent discoloration observed in comparison with standard ascorbic acid, α-tocopherol and quercetin, The compound also exhibited antibacterial activity against methicillin resistant Staphylococcus aureus (ATCC3359) and Bacillus subtilis (clinically isolated) with inhibition zone of 20 and 12 mm, respectively. However the other two xanthones were found to be inactive. For the tyrosinase inhibitory activity, again compound (1) displayed strong activity comparable with the standard kojic acid.

Molecules, Vol. 17, Pages 6056-6070: Physicochemical Characterization and Cytotoxic Activity Evaluation of Hydroxymethylferrocene:β-Cyclodextrin Inclusion Complex

Posted: 21 May 2012 12:00 AM PDT

An inclusion complex of hydroxymethylferrocene (FeMeOH) with β-cyclodextrin (β-CD) was prepared in the solid state by different techniques such as physical mixture, coprecipitation, kneading and freeze-drying. The formation of the inclusion complex was confirmed by X-ray Powder Diffractometry and Fourier Transform-Infrared spectroscopy. In aqueous solution, the 1:1 stoichiometry was established by a Job plot. The inclusion complex formation was also investigated by NMR and the stability constant (Kb) of the complex was determined to be 478 M−1, which is in agreement with that obtained with UV-Vis tritation (Kb = 541.3 M−1). The phase solubility study showed a diagram classified as BS type and that the solubility of FeMeOH was slightly increased in the presence of β-CD. Furthermore, utilizing phase solubility diagram data, the Kb was estimated to be equal to 528.0 M−1. The cytotoxic activity of FeMeOH and its complexation product with β-CD was determined using the MTT-assay on MDA-MB-231 cell line, showing that the inclusion complex has a higher capability of inhibiting cell growth compared to that of pure FeMeOH.

Molecules, Vol. 17, Pages 6046-6055: Effect of Soluble Sulfide on the Activity of Luminescent Bacteria

Posted: 21 May 2012 12:00 AM PDT

Sulfide is an important water pollutant widely found in industrial waste water that has attracted much attention. S2−, as a weak acidic anion, is easy hydrolyzed to HS− and H2S in aqueous solution. In this study, biological tests were performed to establish the toxicity of sulfide solutions on luminescent bacteria. Considering the sulfide solution was contained three substances—S2−, HS− and H2S—the toxicity test was performed at different pH values to investigate which form of sulfide increased light emission and which reduced light emission. It was shown that the EC50 values were close at pH 7.4, 8.0 and 9.0 which were higher than pH 5 and 10. The light emission and sulfide concentrations displayed an inverse exponential dose-response relationship within a certain concentration range at pH 5, 6.5 and 10. The same phenomenon occurred for the high concentration of sulfide at pH 7.4, 8 and 9, in which the concentration of sulfide was HS− >> H2S > S2−. An opposite hormesis-effect appeared at the low concentrations of sulfide.

Runes of Magic - Screenshots

Posted: 21 May 2012 02:45 AM PDT

With an extensive range of features Runes of Magic prepares to redefine the standard of free-to-play MMO games. The German version of the sophisticated fantasy adventure will come to light even before Christmas 2008. The English version will be released soon afterwards. Even at the beginning Runes of Magic conveys its absorbing story in over 600 quests embedded in an atmospheric world. Players can choose from six main classes. Combined with a secondary class they dispose of 36 individual character classes over all. All characters possess unique skills with impressive combo attacks and can use mounts in the later stages of game play. A particularly attractive feature for guilds and even players is the possibility to arrange their own virtual homes with individual furnishing. Thanks to an extensive crafting and reputation system, thrilling PVP as well as demanding dungeons and boss-monsters no wishes remain unsatisfied. MMO fans can find first pictures and a registration form for the newsletter on the official teaser site

Runes of Magic – a world full of wizardry and adventure
In Runes of Magic players explore and discover a magical realm full of wonders and ancient riddles. On their way from simple novice to famous hero, they will always be accompanied by magical runes and potent oracles which are fragments of the divine book Taborea. In Runes of Magic players should use the rune stone wisely, for they might also lure them to a path of destruction. But legend has it, that he, who embraces the oracle and acquires its might, will gain absolute power over the future. It is now up to the player, to write on the history of the world.

To do that, players have access to a dual class system which allows them to freely combine their main and secondary classes, in order to freely build a character the way they want. On their way through Taborea, they learn professions and special ...

Sound Shapes - Screenshots

Posted: 21 May 2012 02:27 AM PDT

Fact sheet pending.

Stunt Bugs

Posted: 12 May 2012 03:33 PM PDT

Platform: iOS, Android — Stunt Bugs An up-and-coming young housefly has a simple wish; He wants to make it to the big city and become the greatest stunt rider that Bugopolis has ever seen. To impress the masses with your skills, you have to drive through multiple trick-tastic levels, collect star balloons, and get money for your trip. There are plenty of other insects along the way to aid Buzz in his quest for glory and they want to show their stuff off to the world. Whether you are looking for a quick physics distraction or an addicting stunt racer, Stunt Bug has got you covered. Tagged as: achievements, adventure, android, arcade, bicycle, game, ios, iphone, mobile, nook, physics, randomhousedigital, rating-g, stunt

Onlytasks 5.4 - Synchronize your tasks with Evernote.. (Commercial)

Posted: 21 May 2012 01:20 AM PDT

Onlytasks allows you, with little effort, sort, classify and prioritize your tasks easily and conveniently. In addition to the book where it is situated and its title, each task can have due date, notes and tags; this allows you to focus on tasks and eliminate unnecessary and superficial information.

Onlytasks for iPhone allows synchronization with an Evernote account so you can also edit your tasks from Evernote and always have a backup of your data.

Onlytasks can help save you time and organize your life with an easy and uncomplicated to use system. It is so convenient you'll enjoy staying more organized and look forward to working with it frequently!

Enter and prioritize your tasks, and later sort, find and classify with no great effort on your part.

Tasks and notes are put into folders or category holders we call "NOTEBOOKS". Inside the Notebooks categories, you create tasks and enter a name/title/label for each one. Every task in your notebook can have optional dates due, tags, and can be marked with a STAR to stand out and be pre-sorted in the "STARS" folder in the STATUS side bar.

There is a flexible notes section where you can type in or paste in several lines of text. The notes section expands as you need more space and is user adjustable to go to the side or bottom of the main window.

Onlytasks is designed to help you drill down and focus, is adaptable to work differently for different people the way they think and it is not over complicated to use.

Onlytasks for Mac OS X allows synchronization with an Evernote account so you can also edit your tasks from Evernote and always have a backup of your data. (Look at for information about keywords that Onlytasks used to identify data in Evernote notes).

Onlytasks for OS X allows partial synchronization with iCal, you can submit your tasks to iCal and create events related to them. These tasks and events remain synchronized in the title and date. You can also choose that when complete a task in Onlytasks delete its event in iCal. You can send a task to iCal through menu Edit -> Send task(s) to iCal or add the appropiate button to your toolbar.

And if you have an iOS device you can use Onlytasks for iOS and have your tasks on your Mac and your iPhone,iPod Touch or iPad perfectly synchronized (using an Evernote account).

Please, don't hesitate to write us with comments, bugs or requests.

Version 5.4:
  • Now, the creation date is editable.

  • New list in Status with all your tasks.

  • Now, you can choose between events or reminder when send tasks to iCal (in this version iCal is called System Calendar).

  • Fixed a bug when sending multiple tasks to iCal.

  • New check box when creating a task to send this task to iCal, immediately after creating it.

  • New, redesigned, view to edit/ create tasks. (See the program help).

  • Other fixes and enhancements.

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Chess Champion Takes on 10 Players Simultaneously

Posted: 21 May 2012 12:15 AM PDT

GRAND JUNCTION, Colo. Damien Nash is currently the two-time Utah State Co-Chess Champion.

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